Efecto cicatrizante y antiinflamatorio del aloe vera y la vitamina c en mucosa oral. Revisión narrativa de la literatura

Abstract

Objective: The objective of this narrative review of the literature was to determine the healing and anti-inflammatory effect of Aloe vera and vitamin C on oral mucosa. Materials and methods: 126 articles related to the objective of the study were collected, these articles were read and analyzed and 50 of them were selected according to the inclusion and exclusion criteria, where the search parameter was the words: “Aloe” “inflammation” “mucosa” “cicatrization” “bacteria” “Ascorbic Acid” “wound healing” and Boolean operators such as “AND and “OR” were used applying the search to a period of the last 20 years. Results: When analyzing the results, it was determined that Aloe vera had a healing and anti-inflammatory effect in various lesions of the oral mucosa since it acts in the arachidonic acid pathway through cyclooxygenase, inhibiting inflammation, and it also did not present side effects in the clinical studies carried out. In patients, with respect to vitamin C it was determined that it has a healing and anti-inflammatory effect on oral mucosa since it regulates the inflammatory process and stimulates tissue repair, in addition, it modulates the release of catabolic inflammatory cytokines, promotes wound healing, Aloe vera had a high antibacterial effect against a variety of oral pathogens. Conclusion: Aloe vera and vitamin C are effective alternative treatments in terms of the healing and anti-inflammatory effect on oral mucosa lesions, however, regarding vitamin C there are no clinical studies regarding its direct topical application on oral mucosa and there is a controversy regarding its dosage. Aloe vera has an antibacterial effect against pathogens of the oral cavity, however, clinical studies are needed to determine what other pathogens Aloe vera can inhibit. Keywords: Aloe, ascorbic acid, mucosa, wound healing, inflammation, bacteria.