Uso de biomarcadores en el cáncer de cavidad oral

Abstract

Cancer is the result of the uncontrolled proliferation of abnormal cells, either caused by genetic (molecular) changes that are transmitted from the parents to their children (hereditary) or that occur in the body throughout the life of a person (acquired). Each type of cancer has a unique group of molecular changes in cancer cells. Technological advances have made molecular testing possible, allowing clinicians to identify the molecular differences between cancer cells and healthy cells. The development of this work aims to propose and develop a study on a marker (or pool of markers) that allows a diagnosis precise state of the pathology and if it is easily obtained through minimally invasive methods, we would be facing an ideal marker that would contribute to timely treatment promoting the quality of life of patients, we will talk about microRNAs, which are small RNAs that regulate the expression of your target genes through decreased expression of proteins encoded by these genes, by repression of translation and / or degradation of its mRNA. MiRNAs play a fundamental role in virtually all cellular processes including development, function and survival. miRNAs are as critical regulators of immune tolerance and autoimmunity, These are as potential new therapeutic targets for the treatment of multiple diseases.