“Mecanismos de acción de los receptores esteroideos que modulan la respuesta protectora en la esclerosis múltiple”.

Abstract

The etiology of Multiple Sclerosis (MS) is complex and causes many changes and alterations at the level of the Central Nervous System (CNS), in addition, for a long time the prevalence of this disease has been increasing globally, with women being the most affected. Although multiple investigations have been carried out, multiple sclerosis is one of the diseases that currently does not have an effective treatment and of the possible therapeutic alternatives that exist, such as steroid hormones, the molecular mechanisms through which act. Therefore, it is necessary to identify the mechanisms of action of the steroid receptors that have been modulating the protective response in multiple sclerosis, through the review of the reported literature that allowed characterizing the mechanisms of action of these steroid receptors taking into account the sexual differences in the modulation of the protective response and that are associated with the relief of the symptoms and the progression of the disease, in order to have a perspective that allows targeted and selective treatments for this disease