Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.

Abstract

Silver nanoparticles are a novel treatment against bacterial infections that exhibit resistance against traditional antibiotic agents resulting in infectious diseases of complex evolution. However, this type of nanoparticles exhibit cytotoxicity on eukaryotic cells, as well as are a substance that generates contamination in the water where it has been used, due to lack of a mechanism for its removal from the environment. As a solution alternative to these problems, it is proposed to develop a nanocomposite consisting of a magnetic core of iron oxide, coated with silica, and decorated with silver nanoparticles. The capacity of the nanostructured compound produced as a bactericidal agent, was evaluated on Gram positive strains and Gram Negatives. The characterization was carried out through by scanning electron microscopy and scanning transmission electron microscopy to determine its morphology, its chemical composition was determined semi-qualitatively by dispersed energy X-ray spectroscopy and its magnetic properties by vibrant sample magnetometry. The study showed that developed nanocomposites can be applied as bactericidal and/or bacteriostatic agents, being an alternative in disinfection processes for microbial control. Finally, by their magnetic property they would facilitate their removal from the environment in which they have been applied, thus allowing to perform a disinfection process without adding additional contaminants to the environment, preventing the accumulation of these in the environment.