1. Universidad Antonio Nariño
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  3. Pregrado
  4. Bioquímica
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Campo DC Valor Lengua/Idioma
dc.contributor.advisorLosada Barragán, Mónica-
dc.contributor.advisorLlamosa Pérez, Daniel-
dc.creatorMedina Castillo, Yehidi Julieth-
dc.date.accessioned2021-02-18T18:33:52Z-
dc.date.available2021-02-18T18:33:52Z-
dc.date.created2020-11-18-
dc.identifier.urihttp://repositorio.uan.edu.co/handle/123456789/1494-
dc.descriptionInternaes_ES
dc.description.abstractNeuroinflammation is characterized by presenting alterations in the blood-brain barrier, and activation of glial cells, leading to brain tissue alterations generating a pathology, this has led to the need to improve the magnetic resonance imaging technique that allows understanding the development and progression of alterations of the blood-brain barrier in real time, under neuroinflammatory conditions. As an alternative to this solution, it is proposed to establish the binding of a neuroinflammation marker peptide with its target protein and its conjugation with superparamagnetic nanoparticles. The results show that the magnetic nanoparticles have a spherical shape with a size of 54 ± 10 nm, the chemical composition Fe @ SiO2 and a magnetic hysteresis curve indicating a superparamagnetic behavior; The evaluation of the binding of peptide-88 with its possible receptor protein showed a greater binding between peptide-88 with laminin β1, likewise the binding of peptide-88 with the nanoparticles was studied, demonstrating a greater binding unlike the target. The present study showed that by establishing the functionalization of superparamagnetic nanoparticles conjugated to a neuroinflammation biomarker peptide, they can be used for early diagnosis and real-time evolution of the mechanisms triggered under neuroinflammatory conditions.es_ES
dc.description.sponsorshipUAN Proyectos de ciencia, tecnología, innovación y creación artísticaes_ES
dc.description.tableofcontentsLa neuroinflamación es caracterizada por presentar alteraciones en la barrera hematoencefálica, y activación de las células glía, conduciendo a eventos patológicos, esto ha llevado a la necesidad de mejorar la técnica de imagen por resonancia magnética que permitan comprender el desarrollo y progresión de las alteraciones de la barrera hematoencefálica en tiempo real, bajo condiciones neuroinflamatorias. Como una alternativa a esta solución, se propone establecer la unión de un péptido marcador de neuroinflamación con su proteína blanco y su conjugación con nanopartículas superparamagnéticas. Los resultados muestran que las nanopartículas magnéticas presentan una forma esférica con un tamaño 54 ± 10 nm, la composición química Fe@SiO2 y una curva de histéresis magnética indicando un comportamiento superparamagnético; la evaluación de la unión del péptido-88 con su posible proteína receptora mostró una mayor unión entre el peptido-88 con laminina β1, igualmente se estudió la unión del péptido-88 con las nanopartículas demostrando una mayor unión a diferencia del blanco. El presente estudio evidenció que al establecer la funcionalización de nanopartículas superparamagnéticas conjugadas a un péptido biomarcador de neuroinflamación, pueden ser utilizadas para el diagnóstico temprano y evolución en tiempo real de los mecanismos desencadenados bajo condiciones neuroinflamatorias.es_ES
dc.language.isospaes_ES
dc.publisherUniversidad Antonio Nariñoes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourceinstname:Universidad Antonio Nariñoes_ES
dc.sourcereponame:Repositorio Institucional UANes_ES
dc.sourceinstname:Universidad Antonio Nariñoes_ES
dc.sourcereponame:Repositorio Institucional UANes_ES
dc.subjectNeuroinflamación, barrera hematoencefálica, nanopartículas superparamagnéticas, péptido biomarcador, proteínas blanco, cultivos in vitro.es_ES
dc.titleEvaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticases_ES
dc.publisher.programBioquímicaes_ES
dc.rights.accesRightsopenAccesses_ES
dc.subject.keywordNeuroinflammation, blood-brain barrier, superparamagnetic nanoparticles, biomarker peptide, target proteins, in vitro cultures.es_ES
dc.type.spaTrabajo de grado (Pregrado y/o Especialización)es_ES
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES
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dc.description.degreenameBioquímico(a)es_ES
dc.description.degreelevelPregradoes_ES
dc.publisher.facultyFacultad de Cienciases_ES
dc.description.funderCT-672-2018, código 123377757091es_ES
dc.description.notesPresenciales_ES
dc.creator.cedula1030649417es_ES
dc.publisher.campusBogotá - Circunvalar-
Aparece en las colecciones: Bioquímica

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