Evaluación in silico de péptidos derivados de la secuencia peptídica 8b-13 hacia el complejo FGF8b/FGFR

Abstract

Prostate cancer is the malignant growth of the prostate gland; It occurs when the cells of the prostate mutate and multiply uncontrollably. Fibroblast growth factor 8b (FGF8b) is expressed in a large percentage of patients with prostate cancer and plays a key role in the appearance and development of this cancer. Various studies have shown that the synthetic peptide 8b-13, derived from the gN helix domain of FGF8b, blocks the interaction of FGF8b with the fibroblast growth factor receptor (FGFR), inhibiting the proliferation of prostate cancer cell lines . To identify the affinity towards the FGF8b/FGFR complex of peptides derived from 8b-13, a peptide library was proposed by making cuts at the amino and carboxyl termini of the 8b-13 sequence. The affinity towards the FGF8b/FGFR complex was evaluated and the key amino acids for the interaction were identified by means of molecular docking tests, using the algorithm of AutoDock Vina, Chimera and Discovery Studio. The results propose viable peptides to be candidates in experimental trials that could demonstrate the inhibition of cancer cell proliferation, developing tools for the possible treatment of prostate cancer.